How has the 'customary nature' of Japanese fisheries reacted to Covid-19? An interdisciplinary study examining the impacts of the pandemic in 2020.

Like many other countries, the economy and society of Japan have been deeply affected by the Covid-19 outbreak, and the fishery sector is no exception. This study takes an interdisciplinary approach to analyze the economic and social impacts of the pandemic on Japanese fisheries, gauging the extent and nature of the damages incurred from Covid-19 while helping to provide tailored post-recovery recommendations for the industry. Using results from an online survey questionnaire (N = 429) and compiling additional economic information from public sources, this study revealed the overwhelmingly negative changes in sales figures and overall financial security that survey participants experienced when compared to a year earlier. High-value and fresh fish species were also significantly affected in 2020 across Japan, in line with similar trends across the developed world. Aquaculture businesses were shown to be more vulnerable to the spread of Covid-19 than small-scale fishing operations, which tend to be more diverse and flexible. Bonding social capital was also shown to be important for mutual help and human well-being, especially among small-scale fishers. This "customary nature" of Japanese fisheries, at the same time, can be seen as a barrier to the transformation of the industry. Given these results, several policy implications are discussed to help fisheries stakeholders and their communities build back better from the Covid-19 pandemic.

Synthesis of low-molecular weight fucoidan derivatives and their binding abilities to SARS-CoV-2 spike proteins.

Fucoidan derivatives 10-13, whose basic sugar chains are composed of repeating α(1,4)-linked l-fucopyranosyl residues with different sulfation patterns, were designed and systematically synthesized. A structure-activity relationship (SAR) study examined competitive inhibition by thirteen fucoidan derivatives against heparin binding to the SARS-CoV-2 spike (S) protein. The results showed for the first time that 10 exhibited the highest inhibitory activity of the fucoidan derivatives used. The inhibitory activity of 10 was much higher than that of fondaparinux, the reported ligand of SARS-CoV-2 S protein. Furthermore, 10 exhibited inhibitory activities against the binding of heparin with several mutant SARS-CoV-2 S proteins, but was found to not inhibit factor Xa (FXa) activity that could otherwise lead to undesirable anticoagulant activity.